Faculty Collaboration Database

Interaction of ambient temperature with the effects of delta 9-tetrahydrocannabinol on brain catecholamine synthesis and plasma corticosterone levels. Psychopharmacology (Berl) 1980;67(3):215-9

Date

01/01/1980

Pubmed ID

6247738

DOI

10.1007/BF00431259

Scopus ID

2-s2.0-0018851676 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

The effects of delta 9-tetrahydrocannabinol (THC) on body temperature, catecholamine synthesis and plasma corticosteroid levels were examined in the mouse at ambient temperatures of 31 degrees, 20 degrees and 10 degrees C in order to study the role of hypothermia in the THC's other actions. THC produced hypothermia at 10 degrees and 20 degrees C, but not at 31 degrees C. Dose related increases in dopamine and norepinephrine synthesis rates and plasma corticosterone levels were produced by THC at both 31 degrees and 20 degrees C. The effects of THC at 10 degrees C were biphasic. These data indicate that the effects of THC on brain catecholamines are not a result of drug induced hypothermia and may be a result of a direct action on neurons.

Author List

Bloom AS, Kiernan CJ

Author

Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Brain
Catecholamines
Corticosterone
Dopamine
Dronabinol
Male
Mice
Mice, Inbred ICR
Neurons
Norepinephrine
Temperature