Faculty Collaboration Database

Adrenalectomy reverses the effects of delta-9-THC on mouse brain 5-hydroxytryptamine turnover. Pharmacology 1981;23(4):223-9

Date

01/01/1981

Pubmed ID

6275421

DOI

10.1159/000137553

Scopus ID

2-s2.0-0019412511 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Acute administration of certain cannabinoids, including delta 9-tetrahydrocannabinol (delta 9- THC), resulted in elevated levels of plasma corticosterone in mice. The rank order potency of these cannabinoids is the same as others have reported using behavioral tests. The maximally effective dose of delta 9-THC (30 mg/kg) in this test also increased the amount of 3H-tryptophan found in the brains of mice given an intravenous injection of 3H-tryptophan 10 min prior to decapitation. This effect was associated with an increase in the amount of 3H-5-hydroxytryptamine synthesized during the pulse period. Adrenalectomy was found to inhibit these effects of delta 9-THC. The possibility that corticosterone may mediate the effects of delta 9-THC on tryptophan disposition and metabolism is discussed.

Author List

Johnson KM, Dewey WL, Bloom AS

Author

Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenalectomy
Animals
Brain
Corticosterone
Dronabinol
Male
Mice
Mice, Inbred ICR
Serotonin
Tritium
Tryptophan