Tumor-to-tumor variability in the hypoxic fractions of experimental rodent tumors. Radiother Oncol 1984 Jun;2(1):57-64
Date
06/01/1984Pubmed ID
6505277DOI
10.1016/s0167-8140(84)80039-0Scopus ID
2-s2.0-0021167694 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Paired determinations of the radiation responses of normally-aerated and artificially hypoxic rodent tumors, performed to measure the hypoxic fractions of the tumors, were obtained from our own laboratories and from the literature. The data were reanalyzed to assess whether the variabilities in the radiation responses of the normally-aerated and artificially hypoxic tumors were similar. If there were large differences in the hypoxic fractions of individual tumors within the experiments, the variability in the data from aerobic tumors would be expected to be greater than the variability in the data from artificially hypoxic tumors (which should all be brought to uniform hypoxia and therefore uniform radioresistance). The analyses revealed the variability to be as great or greater for hypoxic tumors as for normally-aerated tumors. This finding suggests that factors other than tumor-to-tumor differences in oxygenation produce most of the variability in the radiation responses of individual tumors from an experimental tumor line.
Author List
Rockwell S, Moulder JE, Martin DFMESH terms used to index this publication - Major topics in bold
AnimalsCell Survival
Neoplasms, Experimental
Oxygen
Rats
Rats, Inbred Strains
