Faculty Collaboration Database

Assessment of pancreatic ductal penetration of antibiotics. Am Surg 1984 Dec;50(12):666-7

Date

12/01/1984

Pubmed ID

6548883

Scopus ID

2-s2.0-0021749491 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Pancreatic ductal penetration of antibiotics is not uniform. Antibiotic therapy for pancreatic and pancreatic related infections, theoretically, is enhanced by drugs that reach the ductal system. The pancreatic ductal penetrance of Cefamandol (1 gm), Amikacin (7.5 mg/kg), and Chloramphenicol (1 gm) given as a single intravenous dose prior to endoscopic retrograde cholangiopancreatography was studied in ten patients. Serum and pancreatic juice were collected simultaneously, frozen, and later assayed for antibiotic concentration. Each antibiotic achieved its expected therapeutic serum level. In contrast, pancreatic ductal levels of Cefamandol and Amikacin were subtherapeutic, whereas Chloramphenicol levels were therapeutic. Further studies are needed to identify other antibiotics with good pancreatic ductal penetrance.

Author List

Wallace JR, Johnson J, Lucas CE, Cushing R, Ledgerwood AM, Sugawa C

MESH terms used to index this publication - Major topics in bold

Amikacin
Anti-Bacterial Agents
Biological Availability
Cefamandole
Chloramphenicol
Humans
Pancreatic Ducts
Pancreatic Juice