The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand's disease. Blood 1984 Mar;63(3):532-5
Date
03/01/1984Pubmed ID
6607754DOI
10.1182/blood.v63.3.532.bloodjournal633532Scopus ID
2-s2.0-0021344581 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The infusion of 1-deamino-(8-D-arginine)-vasopressin (DDAVP) causes not only an elevation in factor VIII-related antigen (FVIIIR:Ag), but also a marked elevation of plasma von Willebrand antigen II (vWAgII). vWAgII reaches a peak concentration at 60 min and is elevated 3-8-fold over basal levels in normal individuals and individuals with type I, IIA, and IIB von Willebrand's disease. As the mechanism of hemostatic alteration brought about by DDAVP might be due to release of endothelial cell proteins, endothelial cell cultures were performed. The cultures demonstrated synthesis and secretion of vWAgII, as evidenced by the incorporation of 35S-methionine into the vWAgII molecule. Thus, vWAgII, like FVIIIR:Ag, is an endothelial cell protein.
Author List
McCarroll DR, Ruggeri ZM, Montgomery RRAuthor
Robert R. Montgomery MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AntigensArginine Vasopressin
Blood Coagulation Factors
Deamino Arginine Vasopressin
Endothelium
Humans
Immunoelectrophoresis
Infant, Newborn
Male
Umbilical Veins
von Willebrand Diseases
von Willebrand Factor
