Alloimmunization: induction of antileukemic reactivity without modification of anti-host reactivity in H-2-compatible mice. Transplant Proc 1980 Mar;12(1):143-6
Date
03/01/1980Pubmed ID
6966095Scopus ID
2-s2.0-0019223861 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Transplanted immunocompetent cells from CBA (H-2k) mice immunized against individual or pooled lymphoid cells from various allogeneic strains resulted in the elimination of widely disseminated leukemia cells in AKR (H-2k) host mice as measured in a GVL bioassay. In most cases, alloimmunization resulted in reactivity against AKR-L comparable to that observed when CBA donors were specifically immunized with irradiated AKR-L cells. Cells from unimmunized or isoimmunized CBA mice had no detectable GVL reactivity. Alloimmunization caused no increase in the mild GVH reactivity of unimmunized or isoimmunized CBA lymphoid cells transplanted into lethally irradiated nonleukemic AKR hosts; whereas, specific immunization with AKR-LX cells resulted in significantly increased GVH-related mortality.
Author List
Truitt RL, Bortin MM, Rimm AAAuthor
Robert L. Truitt PhD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AKR murine leukemia virusAnimals
Graft vs Host Reaction
H-2 Antigens
Immunization
Immunization, Passive
Leukemia, Experimental
Mice
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
T-Lymphocytes
