Faculty Collaboration Database

Central integration of pulmonary stretch receptor input in the control of expiration. J Appl Physiol Respir Environ Exerc Physiol 1982 May;52(5):1296-315

Date

05/01/1982

Pubmed ID

7096154

DOI

10.1152/jappl.1982.52.5.1296

Scopus ID

2-s2.0-0019984765 (requires institutional sign-in at Scopus site)   41 Citations

Abstract

The dynamics of the central processing of the discharge pattern from vagal pulmonary afferents that mediate the expiratory facilitatory reflex have been investigated. These studies involved the development of mathematical models based on analogs of neurophysiological principles such as temporal summation and threshold crossing. These models, which are capable of predicting the expiratory duration for arbitrary discharge patterns, were verified through comparison of their prediction with experimentally obtained relationships between expiratory duration (TE) and waveform parameters of various input patterns. These relationships were obtained by electrical activation of the largest vagal afferent fibers in bilaterally vagotomized, pentobarbital-anesthetized dogs. A parallel two-component model with long time constants (ca. 0.8 and 18 s) was best able to describe the experimental responses. This model suggests that 1) central integration of pulmonary stretch receptor (PSR) input is similar to long time-constant temporal summation; 2) central inspiratory inhibition (no vagal input) may share a common mechanism with vagal processing; 3) PSR-induced inhibition is a linear function of discharge frequency; and 4) TE depends on both the trajectory of lung deflation and the tonic activity at functional residual capacity. These characteristics embody information regarding specific neural arrangements and properties within the respiratory centers.

Author List

Zuperku EJ, Hopp FA, Kampine JP

Author

Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Action Potentials
Afferent Pathways
Animals
Dogs
Feedback
In Vitro Techniques
Lung
Mechanoreceptors
Models, Neurological
Respiration
Respiratory Center
Vagus Nerve