Pyrethroid effects on operant responding and feeding. Neurobehav Toxicol Teratol 1983;5(3):321-4
Date
05/01/1983Pubmed ID
6877472Scopus ID
2-s2.0-0020956117 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
The effects of permethrin, its cis and trans isomers, and deltamethrin on operant behavior and food intake were examined. Male Sprague-Dawley rats were trained to respond on a VI20 second schedule of food reinforcement. Rats were injected intraperitoneally with pyrethroids or their Emulphor vehicle 20 minutes prior to testing. Technical grade permethrin (15-60 mg/kg) produced a dose-related decrease in operant response rate. The 60 mg/kg dose decreased rates by 60%. Lower doses of cis-permethrin (30 mg/kg) and deltamethrin (2 mg/kg) also produced significant decreases in response rate. A 30 mg/kg dose of trans-permethrin was without effect. Food intake was also measured for 1.5 and 24 hour periods after tech-permethrin treatment. Food intake was decreased over both intervals by the 60 mg/kg dose. The results of these studies indicate that subconvulsive doses of pyrethroid insecticides can have significant effects on learned behavior and food intake.
Author List
Bloom AS, Staatz CG, Dieringer TAuthor
Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsConditioning, Operant
Dose-Response Relationship, Drug
Feeding Behavior
Food Deprivation
Insecticides
Male
Nitriles
Permethrin
Pyrethrins
Rats
Rats, Inbred Strains
