Medical College of Wisconsin
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Congenital malformation in twins. Am J Hum Genet 1980 Jan;32(1):69-78

Date

01/01/1980

Pubmed ID

7189094

Pubmed Central ID

PMC1685925

Scopus ID

2-s2.0-0018840088 (requires institutional sign-in at Scopus site)   84 Citations

Abstract

Data from the population-based Metropolitan Atlanta Congenital Defects Program (MACDP) show that the overall rate of malformed infants, as well as the incidence of several specific defects, is higher for twins than for singletons. This elevated risk appears limited to same sex twins and, hence, is probably related to monozygosity. In addition to an 18-fold increase in risk of fetal death compared to singletons, twins have almost a 50% greater likelihood of congenital malformation.

Author List

Layde PM, Erickson JD, Falek A, McCarthy BJ

Author

Peter M. Layde MS, MD Emeritus Professor in the Emergency Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Congenital Abnormalities
Diseases in Twins
Female
Fetal Death
Georgia
Humans
Infant, Newborn
Male
Population Surveillance
Pregnancy
Registries
Risk
Twins, Monozygotic