Generalized melanosis with malignant melanoma metastasizing to skin--a pathological study with S-100 protein and HMB-45. Clin Exp Dermatol 1993 Sep;18(5):454-7
Date
09/01/1993Pubmed ID
8252770DOI
10.1111/j.1365-2230.1993.tb02250.xScopus ID
2-s2.0-0027504405 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
A patient with primary malignant melanoma localized to the right gluteal region is described. Four years later and after intercurrent influenza, disseminated metastases of malignant melanoma to the skin occurred. After a further 6 months melanodermia developed and lasted until the death of the patient (6 months later). Autopsy revealed melanosis of the visceral organs. Histology taken from internal organs using S-100 protein and HMB-45 melanoma methods confirmed metastases of malignant melanoma to the skin, oral cavity, palatal tonsils, nasal and nasopharyngeal mucosae, lungs, myocardium and brain. The authors discuss the mechanism of melanosis--a rare sign in patients with metastasizing malignant melanoma.
Author List
Péc J, Plank L, Mináriková E, Palencárová E, Rollová Y, Lazárová Z, Auxtová S, Lauko LMESH terms used to index this publication - Major topics in bold
ButtocksFemale
Humans
Melanoma
Melanosis
Middle Aged
Skin
Skin Neoplasms
