Effects of nisoldipine on coronary collateral perfusion and hemodynamics in chronically instrumented dogs. Pharmacology 1989;38(4):263-71
Date
01/01/1989Pubmed ID
2755966DOI
10.1159/000138545Scopus ID
2-s2.0-0024580215 (requires institutional sign-in at Scopus site)Abstract
The effect of a new dihydropyridine slow-channel calcium blocking agent, nisoldipine, on hemodynamics and myocardial blood flow in normal and collateral-dependent areas distal to a chronic coronary artery occlusion were studied in chronically instrumented, conscious dogs. Nisoldipine produced significant and dose-related decreases in arterial blood pressure, an elevation of heart rate and large increases in coronary blood flow velocity. In dogs with an Ameroid constrictor previously implanted to enhance coronary collateral development, this agent produced large increases in perfusion distal to a chronic coronary artery occlusion. In addition, despite a reduction in arterial pressure, nisoldipine preserved renal cortical, intestinal and skeletal muscle blood flow while increasing tissue flow within liver and cerebral cortex. Thus, nisoldipine increases oxygen supply to collateral-dependent myocardium in the presence of reduced driving pressure for collateral perfusion.
Author List
Kenny D, Hartman JC, Brooks HL, Warltier DCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Calcium Channel Blockers
Cardiac Output
Coronary Circulation
Dogs
Female
Heart Rate
Hemodynamics
Male
Nifedipine
Nisoldipine
Ultrasonics
