Improvement of postischemic, contractile function by the calcium channel blocking agent nitrendipine in conscious dogs. J Cardiovasc Pharmacol 1988;12 Suppl 4:S120-4
Date
01/01/1988Pubmed ID
2468853DOI
10.1097/00005344-198806124-00026Scopus ID
2-s2.0-0024267950 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
The effect of the new calcium channel blocking agent, nitrendipine, on recovery of contractile function following a 10-min left anterior descending coronary artery occlusion was studied in conscious dogs instrumented with sonomicrometers in the subendocardium of ischemic and normal regions. Nitrendipine (1.0 and 2.5 micrograms/kg/min i.v.) or drug vehicle was administered 30 min prior to the onset of coronary artery occlusion and continued for 30 min following reperfusion accomplished by inflation and deflation of a vascular balloon cuff. Nitrendipine produced a dose-related reduction in arterial pressure and an increase in heart rate and left circumflex coronary blood flow velocity. At 6 h following reperfusion in control dogs (N = 8), segment shortening was significantly reduced from control levels (71 +/- 10% of control). In comparison, dogs pretreated with nitrendipine (3 micrograms/kg/min i.v.) (n = 8) had significantly greater recovery of segment shortening throughout the reperfusion period (102 +/- 10% of control at 6 h following reperfusion). The data demonstrate that pretreatment with the calcium channel blocking agent enhances the recovery of function in postischemic, reperfused, "stunned" myocardium.
Author List
Warltier DC, Gross GJ, Brooks HL, Preuss KCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Coronary Circulation
Coronary Disease
Dogs
Heart Rate
Myocardial Contraction
Nitrendipine
Perfusion
Propranolol
Time Factors
