Faculty Collaboration Database

Comparative effects of FR 34235, a new slow channel calcium blocker, and nifedipine on hemodynamics and myocardial oxygen consumption in the anesthetized dog. Gen Pharmacol 1983;14(6):677-80

Date

01/01/1983

Pubmed ID

6662348

DOI

10.1016/0306-3623(83)90167-2

Scopus ID

2-s2.0-0021049513 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

Five doses of two dihydropyridine calcium antagonists, FR 34235 and nifedipine, were given intravenously to anesthetized dogs to determine effects on hemodynamics and myocardial oxygen balance. Both agents produced dose-related decreases in mean arterial blood pressure and tension time index with little effect on heart rate, dP/dt or myocardial contractile force except at high doses where small decreases were observed. Coronary blood flow increased markedly in the presence of both agents with a maximum increase observed at doses of 10 and 30 micrograms/kg for FR 34235 and nifedipine, respectively. Both compounds decreased myocardial oxygen extraction at all doses and reduced myocardial oxygen consumption at higher doses. These results indicate that FR 34235, a new slow channel calcium blocker, is a potent coronary vasodilator. In addition, this compound possesses oxygen-sparing activity at higher doses.

Author List

Gross GJ, Warltier DC, Hardman HF

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthesia
Animals
Blood Pressure
Calcium Channel Blockers
Coronary Circulation
Dogs
Female
Hemodynamics
Male
Myocardium
Nifedipine
Oxygen Consumption