Positive inotropic actions of the calcium channel stimulator, Bay k 8644, in awake, unsedated dogs. Basic Res Cardiol 1985;80(3):326-32
Date
05/01/1985Pubmed ID
2411255DOI
10.1007/BF01907908Scopus ID
2-s2.0-0021809478 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
The hemodynamic effects of the dihydropyridine derivative Bay k 8644, a new calcium agonist with positive inotropic actions, were studied in instrumented conscious dogs before and after beta adrenergic blockade with propranolol. Intravenous Bay k 8644 (2, 4, 8 and 20 micrograms/kg/min) produced dose-related increases in arterial and left ventricular systolic pressures and myocardial contractility (+dP/dt; % segment shortening). Coronary blood flow velocity was increased at higher doses. Prior administration of propranolol produced no significant alteration of the hemodynamic effects of Bay k 8644. Increases in arterial and left ventricular pressures produced by Bay k 8644 were controlled by intravenous infusion of sodium nitroprusside with resulting enhancement of positive inotropic effects. The results demonstrate that the hemodynamic responses to this novel calcium agonist with positive inotropic properties are not mediated via beta adrenergic mechanisms and control of increases in arterial pressure lead to enhanced regional contractility.
Author List
Preuss KC, Brooks HL, Gross GJ, Warltier DCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimals
Calcium
Dogs
Dose-Response Relationship, Drug
Female
Hemodynamics
Ion Channels
Male
Myocardial Contraction
Nifedipine
Propranolol
Receptors, Adrenergic, beta
