Faculty Collaboration Database

Subendocardial versus transmural myocardial infarction: relationship to the collateral circulation in canine and porcine hearts. Can J Physiol Pharmacol 1982 Dec;60(12):1700-6

Date

12/01/1982

Pubmed ID

7165863

DOI

10.1139/y82-248

Scopus ID

2-s2.0-0020356236 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

In the present study, the relationship between transmural perfusion gradients and myocardial infarct size and distribution in canine and porcine hearts was characterized. Anesthetized pigs (N = 6) and dogs (N = 7) underwent a 2-h occlusion and 5-h reperfusion of the distal third of the left anterior descending coronary artery. The area at risk for infarction and ultimate infarct size were determined by fluorescein dye infused intracoronary and nitro blue tetrazolium stain, respectively. Myocardial perfusion within normal, ischemic, and infarcted regions was determined by the radioactive microsphere technique in each species. In dogs, infarction was subendocardial and comprised 29.9 +/- 5.5% of the area at risk, while in pigs infarction was transmural and comprised 50.1 +/- 4.2% (p less than 0.05). Collateral perfusion of the subendocardium of infarcted regions in pig and dog hearts was similar (0.05 mL X min-1 X g-1), while flow to the subepicardium was significantly (p less than 0.05) higher in dogs than in pigs (0.25 versus 0.05 mL X min-1 X g-1). The data demonstrate that species differences in myocardial infarct size and shape are related to differences in coronary collateral blood flow. The smaller subendocardial infarction in dog hearts is related to a relatively high subepicardial perfusion and transmural infarction in pig hearts owing to the lack of collateral perfusion in subepicardium as well as subendocardium.

Author List

Warltier DC, Zyvoloski MG, Gross GJ, Brooks HL

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Collateral Circulation
Coronary Circulation
Dogs
Heart Rate
Myocardial Infarction
Species Specificity
Swine