Contrasting effects of pharmacologic vasodilation on true collateral and overlap perfusion in ischemic myocardium. Gen Pharmacol 1984;15(6):471-7
Date
01/01/1984Pubmed ID
6526259DOI
10.1016/0306-3623(84)90201-5Scopus ID
2-s2.0-0021713295 (requires institutional sign-in at Scopus site)Abstract
The effects of chromonar (3.5 and 7.0 mg/kg i.v.), a selective coronary vasodilator, on true collateral blood flow and overlap flow (noncollateral perfusion due to overlapping end arteries of adjacent coronary vessels) were measured independently in anesthetized dogs following acute coronary occlusion. Collateral flow in the ischemic zone was significantly (P less than 0.05) reduced by chromonar in a dose-related manner while transmural overlap flow was increased. True collateral flow was distributed primarily to the subepicardium and chromonar produced a significant reduction in both subepicardial and subendocardial perfusion. Overlap perfusion was distributed equally across the left ventricular wall and chromonar increased perfusion to both subepicardium and subendocardium. The results indicate that there are two independent sources of perfusion of ischemic myocardium and that pharmacologic vasodilation with chromonar produces opposite effects on each: a steal of true collateral blood flow and an increase in overlap perfusion.
Author List
Keelan KE, Gross GJ, Brooks HL, Warltier DCAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsChromonar
Collateral Circulation
Coronary Circulation
Coronary Disease
Coronary Vessels
Coumarins
Dogs
Vasodilation
