Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease. Ann Neurol 1996 Jun;39(6):800-3
Date
06/01/1996Pubmed ID
8651653DOI
10.1002/ana.410390617Scopus ID
2-s2.0-0030009126 (requires institutional sign-in at Scopus site) 35 CitationsAbstract
Inheritance of the apolipoprotein E epsilon 4 allele is a risk factor for Alzheimer's disease (AD). A recent report studying Japanese patients suggested that a polymorphism of a trinucleotide repeat in the 5' untranslated region of an apolipoprotein E receptor, the very-low-density lipoprotein receptor, is genetically associated with AD, with overrepresentation of the allele containing five copies of the repeat. We determined the allele frequencies of the very-low-density lipoprotein receptor in 3 white populations totaling 469 individuals. In contrast to the previous report, we found no differences in allele frequencies between case patients and control subjects. The discrepancy could be due to differences in Japanese and white populations. Nonetheless, these data weaken the likelihood that this polymorphism in the very-low-density lipoprotein receptor gene is strongly associated with AD.
Author List
Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, Jacob HJ, Hyman BTMESH terms used to index this publication - Major topics in bold
AllelesAlzheimer Disease
Apolipoproteins E
Cohort Studies
Genotype
Humans
Japan
Lipoproteins, VLDL
Polymerase Chain Reaction
Polymorphism, Genetic
Trinucleotide Repeats
United States
