Faculty Collaboration Database

Concurrent linear scleroderma and systemic lupus erythematosus: a report of two cases. J Invest Dermatol 1979 Nov;73(5):368-72

Date

11/01/1979

Pubmed ID

315439

DOI

10.1111/1523-1747.ep12550429

Scopus ID

2-s2.0-0018612979 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

Two patients with linear scleroderma (en coup de sabre) developed systemic lupus erythematosus (SLE). This association has been well documented in only one previous case. The presence of high titer antibodies to ribonucleoprotein (RNP) initially led to the diagnosis of the mixed connective tissue disease. Development of more serious clinical involvement and antibodies to Sm (case 1) or native deoxyribonucleic acid (nDNA) (case 2) helped establish a diagnosis of SLE. Use of these studies in the differential diagnosis of systemic rheumatic diseases is disucssed briefly. The presence of anti-RNAP antibodies in patients with localized scleroderma may herald a more serious rheumatic disease.

Author List

Mackel SE, Kozin F, Ryan LM, Sheth KJ, Jordon RE

Author

Lawrence M. Ryan MD Emeritus Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Antibodies, Antinuclear
Biopsy
Child
Diagnosis, Differential
Female
Humans
Lupus Erythematosus, Systemic
Mixed Connective Tissue Disease
Ribonucleoproteins
Scleroderma, Systemic