Quantification of human plasma inorganic pyrophosphate. II. Biologic variables. Arthritis Rheum 1979 Aug;22(8):892-5
Date
08/01/1979Pubmed ID
223578DOI
10.1002/art.1780220813Scopus ID
2-s2.0-0018640893 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Plasma inorganic pyrophosphate (PPi) levels rose predictably (28%) after vigorous systemic exercise and returned to baseline values after 30 minutes of rest. Plasma PPi levels were greater (36%) in femoral venous blood than in femoral arterial blood. Forearm muscular exercise, however, did not result in a detectable rise in plasma PPi levels in antecubital veins. The physiologic reasons for both the systemic exercise effect and the arteriovenous differences remain unknown. Measurement of plasma PPi for 10 consecutive days in a single normal subject under basal conditions, where these and other previously identified biologic variables (fasting and diurnal variation) were controlled, showed a coefficient of variation of 12.7%. Thus biologic variability contributed less to observed variation in plasma PPi than did methodologic errors (coefficient of variation of method = 8%). The striking reproducibility of plasma PPi in this subject suggests that this important metabolite is under rather tight homeostatic control.
Author List
Ryan LM, Kozin F, McCarty DJAuthor
Lawrence M. Ryan MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Calcium PyrophosphateDiphosphates
Humans
Male
Methods
Muscle Contraction
Physical Exertion
