Correlation of plasma angiotensin II concentration and plasma renin activity during acute hypoxia in dogs. Clin Exp Pharmacol Physiol 1985;12(1):91-4
Date
01/01/1985Pubmed ID
2988837DOI
10.1111/j.1440-1681.1985.tb00307.xScopus ID
2-s2.0-0021842018 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
The effects of isocapnic hypoxia on plasma renin activity (PRA) and angiotensin II (AII) concentration were studied in anaesthetized, artificially ventilated dogs. Regression analysis of plasma AII concentration vs PRA, both measured by radioimmunoassay (RIA), was used as an index of converting enzyme activity in vivo. PaO2 decreased from 82 to 30 mmHg but regression analysis did not reveal any inhibition of AII production within the limits of detection of this method (less than 20% inhibition). We conclude that systemic converting enzyme activity, assessed by in vivo measurement and correlation of PRA and AII, is not inhibited by severe hypoxia.
Author List
Raff H, Maselli J, Reid IAAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAngiotensin II
Animals
Dogs
Hypoxia
Lung
Peptidyl-Dipeptidase A
Radioimmunoassay
Renin
