Medical College of Wisconsin
CTSIResearch InformaticsREDCap

Plasma substance P levels in normotensive and hypertensive subjects. Clin Exp Hypertens (1978) 1981;3(2):183-93

Date

01/01/1981

Pubmed ID

6163596

DOI

10.3109/10641968109033659

Scopus ID

2-s2.0-0019831528 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Since substance P is a potent natriuretic, diuretic, and vasodilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186+/-14 pg/ml in normal subjects and 164+/-3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.

Author List

Campbell WB, Holland OB, Gomez-Sanchez CE, Graham RM, Pettinger WA, White AC

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Diet
Humans
Hypertension
Posture
Radioimmunoassay
Sodium
Substance P