Faculty Collaboration Database

In vitro cytotoxicity to alveolar macrophages of tar from a low-Btu coal gasifier. Environ Res 1983 Aug;31(2):484-92

Date

08/01/1983

Pubmed ID

6884305

DOI

10.1016/0013-9351(83)90026-9

Scopus ID

2-s2.0-0020957144 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The cytotoxicity of fractions, subfractions, and some individual components present in tar from a low-Btu coal gasifier was determined in vitro with cultured dog alveolar macrophages. A subfraction of the tar which contained phenols and neutral nitrogen heterocycles was found to be a major contributor to the cytotoxic activity of the tar. Four compounds present in this subfraction were tested individually. Ranked from the most to the least toxic they were: 9-phenanthrol, 2-fluorenol, phenanthridone, and carbazole.

Author List

Hill JO, Royer RE, Mitchell CE, Dutcher JS

MESH terms used to index this publication - Major topics in bold

Animals
Cells, Cultured
Chromatography, Gel
Coal Tar
Dogs
Gas Chromatography-Mass Spectrometry
Macrophages
Pulmonary Alveoli
Structure-Activity Relationship