Faculty Collaboration Database

In vitro and in vivo response after exposure to man-made mineral and asbestos insulation fibers. Am Ind Hyg Assoc J 1983 Aug;44(8):557-61

Date

08/01/1983

Pubmed ID

6312789

DOI

10.1080/15298668391405319

Scopus ID

2-s2.0-0020605791 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

The relative in vitro and in vivo toxicity of several types of manufactured fibrous glass insulation and crocidolite asbestos was investigated to aid in selection of a suitable glass fiber for subsequent use in inhalation exposures. The in vitro cytotoxicity to pulmonary alveolar macrophages of small glass fibers from microfiber insulation (count median diameter (CMD) approximately 0.1-0.2 micrometer) was greater than that of the larger fibers from household insulation (CMD approximately 2.4 micrometers). To screen for in vivo pulmonary toxicity, 2-21 mg of glass or asbestos fibers were administered in divided doses to male Syrian hamsters by intratracheal instillation. Animals were sacrificed at 1, 3.5 and 11 months following initial administration of material. One type of glass microfiber [count median diameter (CMD) approximately 0.1 micrometer] caused deaths from pulmonary edema at early times after instillation. High levels of asbestos, a second glass microfiber (CMD approximately 0.2 micrometer) and one type of household insulation fiber (CMD 2.3 micrometers) all resulted in increase in total collagen and mild pulmonary fibrosis at later times after instillation, although microfiber insulation produced a greater response than household insulation. Asbestos insulation produced the greatest response. A five-day inhalation exposure to a high level of glass microfibers deposited in lung less than 10 percent of the lowest instilled amount which elicited indications of lung injury. This amount did not produce significant biological changes at 1 to 12 months after exposure.

Author List

Pickrell JA, Hill JO, Carpenter RL, Hahn FF, Rebar AH

MESH terms used to index this publication - Major topics in bold

Animals
Asbestos
Asbestos, Crocidolite
Construction Materials
Cricetinae
Environmental Exposure
Glass
Lung Diseases
Macrophages
Male
Mesocricetus
Pulmonary Alveoli
Pulmonary Edema
Pulmonary Fibrosis