Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries. Circulation 1986 Mar;73(3):572-8
Date
03/01/1986Pubmed ID
2936531DOI
10.1161/01.cir.73.3.572Abstract
The data obtained in this study demonstrate that the concentration of serotonin is markedly elevated (18- to 27-fold) at the site of a coronary arterial stenosis in open-chest, anesthetized dogs with cyclic flow variations. Cyclic flow variations in this experimental preparation were abolished by ketanserin, a 5-hydroxytryptamine antagonist, but serotonin concentration at the site of the coronary stenosis remained elevated. The intra-atrial administration of serotonin (0.16 to 1 mg/min) restored cyclic flow variations after they had been abolished by ketanserin. Taken together, these data suggest that serotonin may be one of the important mediators of cyclic flow variations in this experimental preparation.
Author List
Ashton JH, Benedict CR, Fitzgerald C, Raheja S, Taylor A, Campbell WB, Buja LM, Willerson JTAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Coronary Disease
Coronary Vessels
Dogs
Hemodynamics
Ketanserin
Male
Periodicity
Piperidines
Serotonin
