Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction. Basic Res Cardiol 1978;73(6):559-70
Date
11/01/1978Pubmed ID
747615DOI
10.1007/BF01906794Scopus ID
2-s2.0-0018124683 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Acute myocardial infarction was produced in anesthetized dogs by ligation of the left anterior descendens coronary artery. Propranolol (2 mg/kg i.v.) administered 4 hours post ligation was examined for its ability to reduce infarct size estimated by histochemical and enzymatic methods. There was a signficant correlation between these two methods in their estimation of infarct size. Treatment with propranolol significantly decreased infarct size estimated with both methods. It is concluded that some portion of the myocardium can be protected against infarction by pharmacologic intervention as late as 4 hours after the onset of coronary artery occlusion.
Author List
Jesmok GJ, Warltier DC, Gross GJ, Hardman HFAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Creatine Kinase
Dogs
Female
Heart Rate
Hemodynamics
Histocytochemistry
Male
Myocardial Infarction
Oxidoreductases
Propranolol
