Medical College of Wisconsin
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Effect of propranolol and nitroglycerin on hemoglobin--oxygen affinity. Eur J Pharmacol 1976 Mar;36(1):267-71

Date

03/01/1976

Pubmed ID

816659

DOI

10.1016/0014-2999(76)90285-5

Scopus ID

2-s2.0-0017252966 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The effect of propranolol on the oxyhemoglobin dissociation curve (P-50) of coronary venous blood was studied in isolated canine hearts. I.v. administration of propranolol (0.5, 5.0 mg/kg) produced no significant change in P-50 over 4 hr. Following propranolol, an intracoronary infusion of nitroglycerin (10 mug/min) increased P-50. Addition of propranolol (5 X 10(-5) M to 1 X 10(-4)M) to central venous blood in vitro produced a significant increase in P-50. These data indicate that propranolol increases P-50 in vitro but does not increase P-50 in vivo, whereas nitroglycerin increases P-50 In vivo but not in vitro.

Author List

Gross GJ, Warltier DC, Hardman HF

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Gas Analysis
Coronary Vessels
Dogs
Hemodynamics
Hemoglobins
Myocardium
Nitroglycerin
Oxygen
Oxygen Consumption
Oxyhemoglobins
Propranolol