Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5. J Am Acad Dermatol 1999 Apr;40(4):637-9
Date
04/03/1999Pubmed ID
10188690DOI
10.1016/s0190-9622(99)70453-6Scopus ID
2-s2.0-0032999932 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with antiepiligrin cicatricial pemphigoid have been shown to react specifically with the alpha3 chain of laminin 5. We describe the first patient with anti-epiligrin cicatricial pemphigoid in whom circulating IgG autoantibodies directed against the beta3 and gamma2-chains of laminin 5 were detected. Treatment with oral prednisolone was beneficial in controlling the disease.
Author List
Fujimoto W, Toi Y, Okazaki F, Lazarova Z, Yancey KB, Arata JMESH terms used to index this publication - Major topics in bold
AgedAutoantibodies
Cell Adhesion Molecules
Humans
Immunoglobulin G
Male
Microscopy, Immunoelectron
Pemphigoid, Benign Mucous Membrane
