Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat. Br J Cancer Suppl 1978 Jun;3:216-9
Date
06/01/1978Pubmed ID
277231Pubmed Central ID
PMC2149389Scopus ID
2-s2.0-0017819565 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
A combination of the radiosensitizer, metronidazole, and the radioprotector, dimethyl sulfoxide (DMSO), was tested for its effects on the radiation tolerance of rat skin and on the radiosensitivity of the BA1112 rhabdomyosarcoma. The simplest interpretation of the effects of the combined treatment is that: metronidazole radiosensitizes BA1112 in one-fraction but not in five-fraction treatments; metronidazole slightly increases the radiosensitivity of skin in one-fraction treatments; metronidazole radiosensitization is independent of the radioprotection produced by DMSO.
Author List
Moulder JE, Lo PS, Fischer JJMESH terms used to index this publication - Major topics in bold
AnimalsDimethyl Sulfoxide
Metronidazole
Radiation Dosage
Radiation Tolerance
Rats
Rhabdomyosarcoma
Sarcoma, Experimental
Skin
