Medical College of Wisconsin
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The kinetics of S-transnitrosation--a reversible second-order reaction. Anal Biochem 1999 Aug 01;272(2):257-62

Date

07/23/1999

Pubmed ID

10415097

DOI

10.1006/abio.1999.4199

Scopus ID

2-s2.0-0033179843 (requires institutional sign-in at Scopus site)   94 Citations

Abstract

Transnitrosation between thiols and S-nitrosothiols has been suggested to be a mechanism of signal transduction. This kinetics of such reactions fit well to a reversible second-order model. Parameters derived from this model give both the forward and reverse rate constants and the equilibrium position at physiological temperature and pH. In addition, methods are shown for calculating the equilibrium distribution of the nitrosyl function group in mixtures of up to three thiols.

Author List

Hogg N

Author

Neil Hogg PhD Senior Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Glutathione
Hydrogen-Ion Concentration
Kinetics
Models, Chemical
Nitroso Compounds
Penicillamine
S-Nitroso-N-Acetylpenicillamine
Serum Albumin, Bovine
Sulfhydryl Compounds
Temperature
Thermodynamics