Faculty Collaboration Database

Stenosis of the tubular neck: a possible mechanism for progressive renal failure. J Lab Clin Med 1997 May;129(5):567-73

Date

05/01/1997

Pubmed ID

9142053

DOI

10.1016/s0022-2143(97)90011-1

Scopus ID

2-s2.0-0031148215 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Fibrosis in chronic renal failure is closely associated with declining function. Its role in affecting function is less well defined. The radiation model of chronic renal failure was used to examine the tissue distribution of fibrosis and scarring and its role in influencing the loss of function in chronic renal disease. A striking and progressive pattern of fibrosis and narrowing of the glomerulotubular neck was found in irradiated pig kidneys. These narrowed necks increased in prevalence with time after irradiation. At 20 weeks after irradiation, the average neck diameter reduction was 60%, as compared with nonirradiated controls, a percentage that is consistent with a reduction in flow and pressure at this critical point of the nephron. Glomerulotubular neck narrowing may thus directly reduce the glomerular filtration rate of an individual nephron. Fibrotic neck stenoses may be a factor in progressive chronic renal failure.

Author List

Cohen EP, Robbins ME, Whitehouse E, Hopewell JW

MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Disease Progression
Fibrosis
Glomerular Filtration Rate
Kidney Failure, Chronic
Kidney Glomerulus
Kidney Tubules
Swine
Time Factors