Beneficial effects of two specific bradycardic agents AQ-A39 (falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs. J Pharmacol Exp Ther 1986 Aug;238(2):422-8
Date
08/01/1986Pubmed ID
3735124Scopus ID
2-s2.0-0022504030 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
The effects of 2 specific bradycardic agents, AQ-A39 [5,6-dimethoxy-2-[3-([alpha-(3,4-dimethoxy)phenylethyl]methyl-amino) propyl]phthalimidine hydrochloride] and AQ-AH 208 [3,4-dihydro-6,7-dimethoxy-2-]3-[(2-[3, 4-dimethoxy-phenyl)-ethyl]-aminoethyl]propyl[-1(2H)isoquinone] were evaluated for their effects on subendocardial segment shortening (% SS) as measured by sonomicrometry and regional myocardial blood flow (radioactive microspheres) in anesthetized dogs subjected to a 15 min left anterior descending coronary occlusion followed by 3 hr of reperfusion. AQ-A39 (2.5-mg/kg bolus + 100 micrograms/kg/min i.v.) and AQ-AH 208 (0.5-mg/kg bolus + 25 micrograms/kg/min i.v.) were administered 15 min before coronary occlusion, during occlusion and throughout reperfusion. Both agents produced equivalent reductions in heart rate (24%) and the heart rate-systolic pressure product (27%) without any other significant hemodynamic changes. Collateral blood flow to the ischemic area was not different between the drug-treated and control groups. During coronary occlusion and throughout reperfusion, however, % SS was significantly (P less than .05) improved by both agents in the ischemic-reperfused area as compared to a control group. Thus, the beneficial actions of AQ-A39 and AQ-AH 208 on improving the recovery of subendocardial contractile function (% SS) may be explained partially by a reduction in myocardial oxygen requirements as a result of bradycardia. These results suggest that specific bradycardic agents may have potential for treatment of certain types of myocardial ischemia.
Author List
Gross GJ, Daemmgen JWMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Coronary Disease
Dogs
Electrocardiography
Female
Heart Rate
Isoindoles
Male
Myocardial Contraction
Perfusion
Phthalimides
