Faculty Collaboration Database

AQ-AH 208, a new bradycardic agent, increases coronary collateral blood flow to ischemic myocardium. J Cardiovasc Pharmacol 1985;7(6):1048-54

Date

11/01/1985

Pubmed ID

2418287

DOI

10.1097/00005344-198511000-00006

Scopus ID

2-s2.0-0022400010 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

The effect of AQ-AH 208 [3,4-dihydro-6,7-dimethoxy-2-(3 - ((2-(3,4-dimethoxphenyl)ethyl)-amino- methyl)propyl)-1(2H)-isoquinolinone], a new selective bradycardic agent, on coronary collateral perfusion was investigated in anesthetized open-chest dogs following acute occlusion of the left anterior descending coronary artery. AQ-AH 208 (0.3 mg/kg i.v.), propranolol (0.3 mg/kg i.v.), and N-dimethylpropranolol (DMP; 2.5 mg/kg i.v.) were equieffective in reducing heart rate approximately 15%. AQ-AH 208 increased collateral flow to the subepicardium, midmyocardium, and subendocardium by 24, 46, and 35% (p less than 0.05), respectively, while propranolol and DMP had no effect. Atrial pacing to predrug levels in the presence of AQ-AH 208 reduced the increases in collateral flow to the different myocardial layers to 16, 25, and 30%, respectively; however, these increases were still significantly greater than control. It is concluded that part of the AQ-AH 208-induced increase in collateral perfusion is due to an increase in diastolic duration. The nature of the frequency-independent component of the effect is unknown but may be explained by a selective decrease in extravascular coronary resistance in the ischemic zone or an increase in the conductance of large epicardial coronary or collateral vessels.

Author List

Daemmgen JW, Gross GJ

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Cardiovascular Agents
Coronary Circulation
Coronary Disease
Dogs
Female
Isoindoles
Male
Microspheres
Phthalimides
Propranolol