The genetics of osteoporosis. Drugs Today (Barc) 2005 Mar;41(3):205-18
Date
05/11/2005Pubmed ID
15883617DOI
10.1358/dot.2005.41.3.892525Scopus ID
2-s2.0-18244392689 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Osteoporosis is a common health problem among the elderly, especially postmenopausal women. It is characterized by fragile bones susceptible to low-trauma fractures. Osteoporosis is a complex disease determined by genetic and environmental factors, as well as the possible interactions among these factors. Twin and family studies have shown that genetic factors play an important role in osteoporosis. Numerous genetic studies have been performed to hunt for genes underlying the disease risk. In this review, we briefly summarize and discuss the current status of knowledge about osteoporosis, with special emphasis on the progress achieved recently in: 1) heritability and choice of osteoporosis study phenotypes; 2) the approaches for gene mapping and identification for osteoporosis; 3) the candidate gene association studies; 4) the linkage mapping studies for osteoporosis; 5) some potential explanations for the inconsistent results; and 6) the pharmacogenetic studies for osteoporosis.
Author List
Long JR, Xiong DH, Recker RR, Deng HWMESH terms used to index this publication - Major topics in bold
AnimalsDisease Models, Animal
Gene Expression Profiling
Genetic Predisposition to Disease
Humans
Osteoporosis
Proteomics
Risk Factors
