The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury. Basic Res Cardiol 1997 Aug;92(4):201-13
Date
08/01/1997Pubmed ID
9342427DOI
10.1007/BF00788515Scopus ID
2-s2.0-0030763034 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
Cell-cell and cell-matrix interactions are known to be mediated by specific cell adhesion receptors expressed on the cell surface. The characterization of these cell adhesion molecules has allowed researchers to examine their roles in a variety of physiologic and pathophysiologic conditions. Numerous studies have demonstrated that myocardial ischemia-reperfusion injury is an acute inflammatory process in which leukocytes are intimately involved. In this review, we summarize the current data on the leukocyte cell adhesion cascade, focus upon studies which have demonstrated specific cell adhesion molecule interactions which mediate the leukocyte involvement in myocardial ischemia-reperfusion injury and suggest future avenues of exploration and possible clinical implications of the studies reviewed.
Author List
Gumina RJ, Newman PJ, Kenny D, Warltier DC, Gross GJAuthor
David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Adhesion Molecules
Humans
Leukocytes
Myocardial Reperfusion Injury
Receptors, Leukocyte-Adhesion
