Faculty Collaboration Database

Gastric mucosal protection from enteral nutrients: role of motility. J Am Coll Surg 1998 Apr;186(4):434-40

Date

04/17/1998

Pubmed ID

9544958

DOI

10.1016/s1072-7515(98)00048-9

Scopus ID

2-s2.0-0031940889 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

BACKGROUND: Cold restraint stress increases the force of gastric contractions and produces gastric mucosal injury in rats. The aim of our study was to determine whether enteral glucose or hyperglycemia alone would alter the stress-induced gastric motility pattern and ameliorate the associated gastric mucosal injury.

METHODS: Adult male rats underwent surgical placement of gastric catheters, jugular venous catheters, and gastric strain gauge transducers 5 days before cold restraint. Three groups of rats received different substances during the same cold restraint stress protocol. Group 1 received 0.9% NaCl, 2 mL/h infused both intravenously (i.v.) and intragastrically (i.g.); group 2 received 0.9% NaCl, 2 mL/h i.g. plus 25% glucose, 2 mL/h i.v.; and group 3 received 0.9% NaCl, 2 mL/h i.v. plus 25% glucose i.g. Following baseline gastric motility measurements, all rats were restrained for 2 hours at 20 degrees C followed by 2 hours at 4 degrees C.

RESULTS: Restraint even at room temperature increased the force of gastric contractions; the cold environment gradually prolonged gastric contractions. Enteral glucose blunted the effects of stress on gastric motility, increased gastric residual volume, decreased gastric acidity, and prevented gastric mucosal injury. Parenteral glucose had little effect on any gastric parameters.

CONCLUSIONS: Enteral glucose prevents the abnormal gastric motility pattern that is necessary to produce the gastric mucosal injury associated with cold restraint stress, but hyperglycemia alone has little effect on the pathophysiology of cold restraint.

Author List

Ephgrave KS, Brasel KJ, Cullen JJ, Broadhurst KA

MESH terms used to index this publication - Major topics in bold

Animals
Cold Temperature
Enteral Nutrition
Gastric Acidity Determination
Gastric Mucosa
Gastrointestinal Motility
Glucose
Male
Rats
Rats, Sprague-Dawley
Restraint, Physical
Stress, Physiological