Faculty Collaboration Database

Mycotic aneurysm of the thoracic aorta due to Aspergillus terreus: case report and review. Clin Infect Dis 2000 Nov;31(5):1144-8

Date

11/14/2000

Pubmed ID

11073743

DOI

10.1086/317467

Scopus ID

2-s2.0-0034457901 (requires institutional sign-in at Scopus site)   36 Citations

Abstract

Mycotic aneurysms of the aorta caused by fungi are uncommon. We describe an unusual case of aortic aneurysm infection caused by Aspergillus terreus, which most likely spread from an adjacent pulmonary focus. Successful treatment included partial pneumonectomy, resection of the aneurysm with graft repair, and prolonged sequential administration of amphotericin B and itraconazole. A review of the published experience with aortic aneurysms caused by Aspergillus species is also presented. When invasive aspergillosis is suspected in proximity to areas with major vascular structures in immunocompromised patients, further investigation to rule out vascular invasion may be warranted. If the diagnosis is confirmed, aggressive and prompt treatment with antifungal agents combined with surgical debridement is essential to improve outcome.

Author List

Silva ME, Malogolowkin MH, Hall TR, Sadeghi AM, Krogstad P

MESH terms used to index this publication - Major topics in bold

Aneurysm, Infected
Aortic Aneurysm
Aspergillosis
Aspergillus
Child
Humans
Male