Faculty Collaboration Database

Improved method of canine decerebration. J Appl Physiol (1985) 1998 Aug;85(2):747-50

Date

08/04/1998

Pubmed ID

9688755

DOI

10.1152/jappl.1998.85.2.747

Scopus ID

2-s2.0-0031880079 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

We describe an improved decerebration method for dogs that is suitable for studies of brain stem neurons in the absence of anesthesia. Previously reported techniques of canine decerebration often lead to respiratory and hemodynamic instability and lack of typical decerebrate rigidity. We have developed a precise, visually controlled, midcollicular brain stem transection technique that overcomes these problems. Our method results in only moderate blood loss while preserving carotid and basilar artery circulations. Consistent levels of brain stem transection routinely lead to stable postdecerebration hemodynamic parameters, allowing prolonged brain stem neuronal recordings. The same model should also be useful for a variety of studies involving other physiological systems in dogs in the absence of anesthesia and for studies of anesthetic effects.

Author List

Tonkovic-Capin M, Krolo M, Stuth EA, Hopp FA, Zuperku EJ

Authors

Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthesia
Animals
Blood Loss, Surgical
Blood Pressure
Brain
Brain Stem
Carbon Dioxide
Decerebrate State
Dogs
Heart Rate
Respiratory Mechanics