Medical College of Wisconsin
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Formation of calcium pyrophosphate crystals: biologic implications. Curr Opin Rheumatol 2000 May;12(3):219-22

Date

05/10/2000

Pubmed ID

10803752

DOI

10.1097/00002281-200005000-00011

Scopus ID

2-s2.0-0034058308 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

The formation of calcium pyrophosphate dihydrate (CPPD) crystals in articular cartilage marks the earliest known phase of CPPD deposition disease. Although the exact mechanisms through which these crystals form remains unknown, work over the last year has added useful details to our current paradigms of crystal nucleation and growth. Key advances include (1) progress in understanding pyrophosphate elaboration and its modifiers, (2) further characterization of the enzymes responsible for pyrophosphate elaboration, and (3) the discovery of an association between two seemingly unrelated metabolic risk factors for CPPD deposition disease.

Author List

Rosenthal AK

Author

Ann K. Rosenthal MD Associate Dean, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Arthritis, Rheumatoid
Calcium Pyrophosphate
Cartilage, Articular
Chondrocytes
Crystallization
Cytokines
Extracellular Matrix
Growth Substances
Humans