Faculty Collaboration Database

Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice. Neoplasia 2007 May;9(5):401-5

Date

05/31/2007

Pubmed ID

17534445

Pubmed Central ID

PMC1877981

DOI

10.1593/neo.07160

Scopus ID

2-s2.0-34249002243 (requires institutional sign-in at Scopus site)   46 Citations

Abstract

Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by approximately 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.

Author List

Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS, You M

MESH terms used to index this publication - Major topics in bold

Aerosols
Animals
Anticarcinogenic Agents
Benzo(a)pyrene
Catechin
Female
Lung Neoplasms
Mice