A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Hum Genet 2007 Mar;121(1):145-8
Date
11/23/2006Pubmed ID
17115187DOI
10.1007/s00439-006-0286-yScopus ID
2-s2.0-33947245930 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
Author List
Zhao LJ, Xiao P, Liu YJ, Xiong DH, Shen H, Recker RR, Deng HWMESH terms used to index this publication - Major topics in bold
FamilyFemale
Genetic Linkage
Genome, Human
Humans
Male
Obesity
Phenotype
Quantitative Trait Loci
