Faculty Collaboration Database

Practical illustrations in tissue engineering: surgical considerations relevant to the implantation of osteoinductive devices. Tissue Eng 2000 Aug;6(4):449-60

Date

09/19/2000

Pubmed ID

10992440

DOI

10.1089/107632700418155

Scopus ID

2-s2.0-0033838969 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

This paper provides practical illustrations in the use of osteoinductive devices (biomaterial carriers coupled with osteoinductive morphogens) for bone tissue engineering. We discuss the considerations relative to the implantation of these devices that may induce tissues that are located outside the boundaries of the osteoinductive device as well as outside boundaries of the normal skeletal envelope. Five reports of osteoinductive devices generating such tissues are reviewed. Histologic and radiographic data from a sixth example are presented and compared with histologic and radiographic findings typical of two varieties of myositis ossificans. A theory is advanced that osteoinductive implants may induce ectopic tissues that resemble fibro-osseous pathologies. Finally characteristics of tissue-engineered bone graft substitutes that may contribute to development of these pathologies and device characteristics that may obviate these ectopic tissues are considered.

Author List

Vögelin E, Jones NF, Huang JI, Brekke JH, Toth JM

Author

Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Animals
Biocompatible Materials
Biomedical Engineering
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Bone Substitutes
Bone and Bones
Humans
Osteogenesis
Recombinant Proteins
Transforming Growth Factor beta