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Unraveling the mechanism for respiratory rhythm generation. Bioessays 2000 Jan;22(1):6-9

Date

01/29/2000

Pubmed ID

10649284

DOI

10.1002/(SICI)1521-1878(200001)22:1<6::AID-BIES3>3.0.CO;2-Q

Scopus ID

2-s2.0-0033980340 (requires institutional sign-in at Scopus site)   41 Citations

Abstract

Breathing is generated by a neuronal network located within the caudal brainstem. One area of particular significance for respiratory rhythm generation is the pre-Bötzinger (preBotC) complex in the ventrolateral medulla. An important step towards understanding the cellular and network basis by which neurons within this region generate the respiratory rhythm was made in a recent study by Koshiya and Smith.(1) Using simultaneous image analysis and electrophysiological techniques these authors identified a discrete population of synaptically-coupled pacemaker neurons within the preBotC. They postulated that these neurons constitute the minimal essential network component (kernel) for generating the respiratory rhythm. BioEssays 22:6-9, 2000.

Author List

McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ

Author

Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Biological Clocks
Medulla Oblongata
Neurons
Respiratory Mechanics