Faculty Collaboration Database

LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene 2003 Feb 27;22(8):1243-6

Date

02/28/2003

Pubmed ID

12606951

Pubmed Central ID

PMC3438910

DOI

10.1038/sj.onc.1206192

Scopus ID

2-s2.0-0037468253 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung adenocarcinomas and large cell carcinomas containing a Kras2 mutation exhibited allelic loss of the wild-type Kras2 allele when a correlation between LOH of the region on chromosome 12p and Kras2 mutation was made. These results from human lung cancer tissues provide a strong evidence in support of our previous observation in mouse models that the wild-type Kras2 is a tumor suppressor of lung cancer.

Author List

Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Alleles
Carcinoma, Large Cell
Chromosomes, Human, Pair 12
Genes, Tumor Suppressor
Genotype
Humans
Loss of Heterozygosity
Lung Neoplasms
Neoplasm Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins