Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility. Exp Lung Res 2005 Mar;31(2):165-77
Date
04/13/2005Pubmed ID
15824019DOI
10.1080/01902140490495543Scopus ID
2-s2.0-14644388822 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
In the present study, the authors performed a comparative sequence analysis of the K-ras gene. By comparing sequences from different mouse inbred strains, the authors have identified new nucleotide polymorphisms in the noncoding regions of mouse K-ras gene. They have also identified noncoding DNA segments evolutionarily conserved among the human, mouse, and rat. Computational analysis for transcription factor binding sites suggests that these polymorphic and conserved DNA sequences harbor potential cis-regulatory elements, which may contribute to the transcriptional regulation of the K-ras gene. Further studies on these potential regulatory sites may help to elucidate the fundamental mechanism underlying allele-specific activation and expression of K-ras gene in hybrid mouse lung tumors, which determines lung tumor susceptibility in mice.
Author List
Wang M, Wang Y, You MMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Binding Sites
Conserved Sequence
DNA, Neoplasm
Gene Deletion
Genes, ras
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Mice
Mice, Inbred Strains
Molecular Sequence Data
Polymorphism, Genetic
Promoter Regions, Genetic
Rats
Sequence Homology, Nucleic Acid
Transcription Factors
