The role of irradiation in central nervous system treatment and prophylaxis for acute lymphoblastic leukemia. Cancer 1976 Jun;37(6):2729-35
Date
06/01/1976Pubmed ID
1065467DOI
10.1002/1097-0142(197606)37:6<2729::aid-cncr2820370624>3.0.co;2-mScopus ID
2-s2.0-0017164585 (requires institutional sign-in at Scopus site) 35 CitationsAbstract
The results of central nervous system (CNS) treatment with craniocervical irradiation and intrathecal methotrexate in 117 children with ALL achieved at the Joint Center for Radiation Therapy. The Children's Hospital Medical Center, and The Sidney Farber Cancer Center are presented. A classification related to meningeal disease which correlated with prognosis is presented and the patients are analyzed within these groups. Of 80 patients classified in the most favorable groups (I and II), no child has suffered primary CNS relapse. Of the remaining 37 patients in less favorable groups (III, IV, and V), eight patients have experienced CNS relapse, five following or in conjunction with bone marrow relapse. The technical features of irradiation are reviewed and related to success of the treatment.
Author List
Dritschilo A, Cassady JR, Camitta B, Jaffe N, Furman L, Traggis DAuthor
Bruce m. Camitta Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentCentral Nervous System
Child
Child, Preschool
Humans
Injections, Spinal
Leukemia, Lymphoid
Methotrexate
