The use of designer rats in the genetic dissection of hypertension. Curr Hypertens Rep 2001 Feb;3(1):12-8
Date
02/15/2001Pubmed ID
11177702DOI
10.1007/s11906-001-0072-0Scopus ID
2-s2.0-0035256962 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
The rat is a well-established model for hypertension research, in both physiologic and pharmacologic study. Quantitative trait loci (QTL) for blood pressure and related phenotypes have been described on every rat chromosome; therefore, more simplified models must be generated to identify and study the function of the gene(s) located by QTL analysis. Designer rat strains, such as congenic and consomic strains, which share phenotypic and genotypic characteristics with humans but with a greatly simplified genetic background, would yield a powerful platform for functional studies, especially when combined with microarray technologies. Development of these designer rats would result in better-defined disease models that can be used in physiologic and applied pharmacologic studies to better treat human essential hypertension.
Author List
Kwitek-Black AE, Jacob HJAuthor
Anne E. Kwitek PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnimals, Congenic
Disease Models, Animal
Humans
Hypertension
Models, Animal
Quantitative Trait, Heritable
Rats
