Reperfusion injury: does it exist? J Mol Cell Cardiol 2007 Jan;42(1):12-8
Date
10/31/2006Pubmed ID
17069848Pubmed Central ID
PMC1876792DOI
10.1016/j.yjmcc.2006.09.009Scopus ID
2-s2.0-33845675393 (requires institutional sign-in at Scopus site) 113 CitationsAbstract
It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se, still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: 'postconditioning' (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway.
Author List
Gross GJ, Auchampach JAAuthor
John A. Auchampach PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenosineAnimals
Humans
Ischemic Preconditioning, Myocardial
Ligands
Models, Cardiovascular
Myocardial Reperfusion Injury
Receptors, Opioid
Receptors, Purinergic P1
