Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. FEBS Lett 2003 Nov 06;554(1-2):88-94
Date
11/05/2003Pubmed ID
14596920DOI
10.1016/s0014-5793(03)01110-4Scopus ID
2-s2.0-0142215651 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
We examined the effect of sodium butyrate on in vitro angiogenesis and cyclooxygenase (COX) expression using primary cultures of human intestinal microvascular endothelial cells (HIMEC). Butyrate inhibited VEGF-induced cellular proliferation, transmigration and tube formation of HIMEC. Butyrate also inhibited COX-2 expression as well as prostaglandin (PG)E2 and PGI2 production, and administration of PGI2 analog partially reversed the effect of butyrate on HIMEC angiogenesis. These results indicate that sodium butyrate inhibits HIMEC angiogenesis through down-regulation of COX-2 expression and PG production, and suggest that anti-angiogenic mechanisms may also be involved in the inhibitory effect of sodium butyrate on tumor growth.
Author List
Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DGAuthor
Mary F. Otterson MS, MD Emeritus Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Angiogenesis InhibitorsButyrates
Cell Division
Cell Movement
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Dinoprostone
Drug Antagonism
Endothelium, Vascular
Epoprostenol
Humans
Intestines
Isoenzymes
Membrane Proteins
Microcirculation
Neovascularization, Physiologic
Prostaglandin-Endoperoxide Synthases
Vascular Endothelial Growth Factor A
