[Effect of stimulation of mu-opiate receptors on contractility of the isolated heart in normal oxygenation and during ischemia-reperfusion]. Ross Fiziol Zh Im I M Sechenova 2001 May;87(5):649-58
Date
07/17/2001Pubmed ID
11452799Scopus ID
2-s2.0-0035348039 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Activation of mu-opioid receptor (OR) in rats prevented development of reperfusion-induced myocardial cell damage. In contrast, direct cardiac mu-OR stimulation with the opioid receptor agonist DAMGO decreased cardiac contractility in normal oxygenation and aggravated the reperfusion-induced myocardial cell damage. The findings suggest that the cardioprotective effect of mu-OR stimulation is not mediated via cardiac mu-OR activation.
Author List
Lasukova TV, Maslov LN, Lishmanov IuB, Tam SV, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-
In Vitro Techniques
Myocardial Contraction
Myocardial Reperfusion Injury
Oligopeptides
Rats
Rats, Wistar
Receptors, Opioid, mu
