Faculty Collaboration Database

Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature. J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6

Date

01/05/2012

Pubmed ID

22215101

DOI

10.1097/MPH.0b013e31823dd370

Scopus ID

2-s2.0-84855450379 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

We describe the case of a 7-year-old white boy who presented with a mixed malignant germ cell tumor with predominant embryonal carcinoma component. The patient underwent right ventriculoperitoneal (VP) shunt placement for hydrocephalus at the time of diagnosis. He received multiagent chemotherapy followed by second-look surgery. Despite an initial response to chemotherapy, the patient had metastatic progression of disease within the craniospinal axis. He received craniospinal radiation and high-dose chemotherapy. Although, he had resolution of central nervous system (CNS) disease, follow-up off treatment revealed extra-abdominal metastases. This is a rare case to discuss abdominal metastasis of a CNS germ cell tumor in a patient with a VP shunt. The influence of VP shunt placement on treatment and management decisions of patients with CNS tumors will be discussed.

Author List

Belongia M, Jogal S

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Child
Humans
Male
Neoplasms, Germ Cell and Embryonal
Peritoneal Neoplasms
Ventriculoperitoneal Shunt